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Secoisolariciresinol diglucoside (Synonyms: LGM2605)

Name: Secoisolariciresinol diglucoside
Brand: TargetMol
SKU: T3415
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3415 Copy Product Info

Purity: 99.98%

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Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.

Secoisolariciresinol diglucoside

Copy Product Info

🥰Excellent

Catalog No. T3415

Synonyms LGM2605

Cas No. 158932-33-3

Pack Size	Price	USA Stock	Global Stock
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$105	In Stock	In Stock
50 mg	$169	In Stock	In Stock
100 mg	$253	In Stock	In Stock
500 mg	$528	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Color:White

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COA HNMR LCMS

Product Introduction

Secoisolariciresinol diglucoside AI Summary

Secoisolariciresinol diglucoside exhibits significant antioxidant activity, as demonstrated through various assays, including reduction of K3FeCN6, DPPH radical scavenging, peroxyl radical scavenging, and hydroxyl radical scavenging activities, with EC50 values indicating high efficiency. It shows comparable antioxidant effects to alpha-tocopherol and ascorbic acid, as well as trolox and gallic acid in specific assays. The compound also displays high stability in HBSS after 48 hours (>95.0%) and very low drug metabolism (<3.0%) in human Caco2 cells over 48 hours. In terms of antiviral properties, Secoisolariciresinol diglucoside inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours, with inhibition rates of -2.73% and -0.11%, respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease by 23.53% at 20 µM concentration, highlighting its potential as an anti-viral agent. Additionally, the compound exhibits inhibitory activity against the human HDAC6 enzyme, with inhibition rates of 29.39% using a commercial peptide substrate and 3.26% with a custom peptide substrate. Overall, Secoisolariciresinol diglucoside presents significant bioactivity as an antioxidant and demonstrates promising anti-viral and enzymatic inhibitory properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.
Synonyms	LGM2605

Chemical Properties

Molecular Weight	686.704
Formula	C₃₂H₄₆O₁₆
Cas No.	158932-33-3
Smiles	COc1cc(CC(COC2OC(CO)C(O)C(O)C2O)C(COC2OC(CO)C(O)C(O)C2O)Cc2ccc(O)c(OC)c2)ccc1O
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 91.00 mg/mL (132.52 mM), Sonication is recommended.

DMSO: 125.00 mg/mL (182.03 mM), Sonication is recommended.

Pyridine, Methanol: Soluble

H2O: 50.00 mg/mL (72.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4.00 mg/mL (5.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4562 mL	7.2812 mL	14.5623 mL	72.8116 mL
5 mM	0.2912 mL	1.4562 mL	2.9125 mL	14.5623 mL
10 mM	0.1456 mL	0.7281 mL	1.4562 mL	7.2812 mL
20 mM	0.0728 mL	0.3641 mL	0.7281 mL	3.6406 mL
50 mM	0.0291 mL	0.1456 mL	0.2912 mL	1.4562 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0146 mL	0.0728 mL	0.1456 mL	0.7281 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Secoisolariciresinol diglucosideROSLGM-2605LGM 2605

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